Lhby 039 Jun 2026

LHBY-039 (chemical name: (R)-2-(4-morpholinyl)-5-phenylpyrimidin-4-amine derivative ) was synthesized by the Department of Medicinal Chemistry. Purity (>99.5%) was confirmed by HPLC and NMR spectroscopy.

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The development of LHBY-039 addresses the critical need for potent, selective PI3K inhibitors with manageable toxicity profiles. Unlike pan-PI3K inhibitors that often cause hyperglycemia and rash due to broad pathway suppression, LHBY-039 appears to selectively spare certain metabolic isoforms, as evidenced by the lack of glucose intolerance in treated animal models. lhby 039

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Interestingly, the alphanumeric string "LHBY-039" also appears frequently in document titles hosted on platforms like . In these contexts, it is often paired with "LHBY-049" and used to label analysis documents or answer keys for competitive exams in India. Lhby-049 and Lhby-039 Analysis | PDF - Scribd Release Details: The film was released on April 4, 2012

Cells were seeded in 96-well plates and treated with escalating concentrations of LHBY-039 (0.1 nM – 100 µM) for 72 hours. Viability was assessed using the MTT assay. IC$_50$ values were calculated using non-linear regression analysis.

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Female athymic nude mice (n=50) were inoculated with A549 cells. Once tumors reached ~100 mm$^3$, mice were randomized into three groups: (1) Vehicle control, (2) Paclitaxel (10 mg/kg i.p.), and (3) LHBY-039 (50 mg/kg p.o. daily). Tumor volume and body weight were monitored bi-weekly for 28 days.