Mukd-546 !!top!! -

No significant accumulation observed after multiple dosing (steady‑state reached by Day 5).

| Cell Line | Mutation | IC₅₀ (nM) | |-----------|----------|-----------| | MIA‑PaCa‑2 | KRAS‑G12C | 45 ± 3 | | PANC‑1 | KRAS‑G12D | 62 ± 5 | | A375 | BRAF‑V600E | 28 ± 2 | | SK‑MEL‑28 | BRAF‑V600E | 32 ± 3 | | A549 | KRAS‑G12S | 78 ± 6 | | HCT‑116 | KRAS‑G13D | 71 ± 5 | | Others (non‑mutated) | – | 210‑480 | mukd-546

Mukd‑546; MEK inhibitor; MAPK/ERK pathway; pre‑clinical oncology; targeted therapy; KRAS; BRAF BRAF The title refers to "off-paco

The title refers to "off-paco," a Japanese slang term for sexual encounters arranged through social media or offline meetups. mukd-546