I have broken it down by (credited in the opening titles) and recurring/notable supporting cast .
| Actor | Character | Notes | | :--- | :--- | :--- | | | Henry Pope | Warden of Fox River State Penitentiary (Seasons 1–2, 4) | | John Heard | Governor Frank Tancredi | Sara's father (Seasons 1–2) | | Patricia Wettig | Vice President / President Caroline Reynolds (later Goodman) | Main antagonist (Seasons 1–2) | | Peter Stormare | John Abruzzi | Mafia boss in Fox River (Seasons 1–2) | | Lane Garrison | David "Tweener" Apolskis | Young inmate (Seasons 1–2) | | Silas Weir Mitchell | Charles "Haywire" Patoshik | Mentally unstable inmate (Seasons 1–2) | | Frank Grillo | Nick Savrinn | Veronica's ally / lawyer (Season 1) | | Kristin Lehman | Agent Jane Phillips | Kellerman's partner (Season 2) | | Leon Russom | General Jonathan Krantz (The General) | Head of The Company (Seasons 4–5) | | Cress Williams | Wyatt Mathewson | Company hitman (Season 4) | | James Hiroyuki Liao | Roland Glenn | Member of Mahone's Scylla team (Season 4) | | Steve Mouzakis | Cyclops | One of T-Bag's men in Yemen (Season 5) | | Rick Yune | Ja | Leader of a terrorist group in Yemen (Season 5) | | Kunal Sharma | Sid | T-Bag's associate in Yemen (Season 5) | | Marina Benedict | Emily "A&W" Blake | Poseidon's assistant / antagonist (Season 5) | full cast of prison break
Prison Break (TV Series 2005–2017) - Full cast & crew - IMDb I have broken it down by (credited in
Wrongfully convicted of murdering the Vice President's brother, Lincoln is the "muscle" to Michael's "brain." Purcell brought a gritty, raw vulnerability to the role of a man facing execution for a crime he didn't commit. The Fox River Eight (And Key Inmates) She becomes the love interest for Michael and
Sara is the prison doctor and the daughter of the Governor of Illinois. She becomes the love interest for Michael and a key component of the escape plan. Callies plays Sara not as a damsel in distress, but as a woman battling her own demons (a recovering addict) with a strong moral compass. Her romance with Michael provides the emotional stakes for Seasons 1 and 2.