A common and effective split for a robust destroyer is a .
Regardless of the primary build path, three specific active skills are mathematically superior for the Destroyer class:
Dual-wield 1-handed Swords, Axes, or Maces. Look for high DPS, Health Steal, Mana Steal, and Critical Hit bonuses.
A rapid flurry of attacks that hits all enemies in your path. This is your main boss-killer and crowd-control skill.
While less common due to slower clear speeds, the defensive build is necessary for clearing the infinite "Shadow Vault" levels at depth 100+ where enemies deal exponential damage.