Yes – unless you’re stuck on an ancient OS. The 4.8.1 runtime is with any app built for .NET Framework 4.0 through 4.8. It will run without recompilation.
(offline installer):
To install .NET Framework 4.8.1 offline, you will need to download the dotNetFx48_Full_x86_x64.exe (or dotNetFx48_Full_setup.exe for web installer) and then run it on the target machine. .net framework 4.8.1 installer